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Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia.

Christian Sandøe Musaeus1, Jette Stokholm Pedersen1, Troels Wesenberg Kjær2,3

  • 1Danish Dementia Research Centre (DDRC), Rigshospitalet and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

Frontiers in Aging Neuroscience
|September 30, 2021
PubMed
Summary

CHMP2B gene mutations cause frontotemporal dementia (FTD). EEG microstate analysis revealed altered brain network dynamics in symptomatic and pre-symptomatic carriers, suggesting potential biomarkers for neurodegeneration.

Keywords:
CHMP2BEEGFTDFrontotemporal dementiamicrostatesmicrostates analysisspectral power

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Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Frontotemporal dementia (FTD) is a neurodegenerative disorder.
  • CHMP2B gene mutations cause a rare, autosomal dominant form of FTD (CHMP2B-FTD).
  • CHMP2B-FTD patients exhibit distinct executive dysfunction and offer insights into early electroencephalographic (EEG) changes.

Purpose of the Study:

  • To investigate EEG microstate dynamics in CHMP2B-FTD.
  • To compare symptomatic and pre-symptomatic CHMP2B mutation carriers with non-carriers.
  • To explore potential early electrophysiological markers of neurodegeneration.

Main Methods:

  • EEG microstate analysis was performed on symptomatic CHMP2B-FTD patients (n=5), pre-symptomatic carriers (n=5), and non-carriers (n=6).
  • Data was parsed into four archetypal microstates, and global power was calculated.
  • Microstate occurrence and duration were analyzed in relation to disease duration and symptom onset.

Main Results:

  • A trend towards lower occurrence of microstate D was observed in CHMP2B-FTD patients (p=0.177).
  • Patients with recent symptom onset (<1 year) showed increased microstate D duration.
  • Patients with longer disease duration (>2 years) exhibited decreased microstate D duration.

Conclusions:

  • EEG microstate analysis reveals dynamic changes in brain networks associated with CHMP2B-FTD.
  • The biphasic pattern of microstate D duration may reflect neurodegenerative processes.
  • These findings could inform the development of biomarkers for early detection and monitoring of neurodegenerative diseases.