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Acute Mycophenolate Mofetil Overdose Managed Conservatively

Prabhat Sharma1,2, Ashish Guragain2, Sunil Adhikari3

  • 1Internal Medicine, Shankarapur Hospital, Kathmandu, NPL.

Cureus
|September 30, 2021
PubMed

Insights

Mycophenolate mofetil (MMF) overdose is rare but generally safe, even in large doses. A 17-year-old survived a 19g MMF overdose with only mild headaches, showing the drug's low toxicity.

Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Medicine

Background:

  • Mycophenolate mofetil (MMF) is a widely used immunosuppressant for post-transplant and inflammatory conditions.
  • MMF is generally considered safe with a low incidence of adverse effects.

Observation:

  • A case of acute overdose involving 19 grams of MMF was managed in a 17-year-old female with suicidal intent.
  • The patient had no significant prior medical history.

Findings:

  • The patient experienced only mild headaches following the MMF overdose.
  • No other symptoms, laboratory abnormalities, or complications were observed.

Implications:

  • This case suggests a potentially wider safety margin for MMF than previously established.
  • Further research into MMF overdose management and toxicity profiles is warranted.
Keywords:
adverse effectsmycophenolate mofetilmycophenolic acidoverdosepoisoningtoxicity

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