An Individual Patient's "Body" on Chips-How Organismoid Theory Can Translate Into Your Personal Precision Therapy...

Area of Science:

• Biotechnology and Regenerative Medicine
• In Vitro Modeling
• Personalized Medicine

Background:

• Early concepts of 'human-on-a-chip' aimed to emulate human physiology in vitro for personalized therapies.
• Recent advancements in human organoids demonstrate the feasibility of self-assembling miniature organ models from stem cells.

Purpose of the Study:

• To develop the 'human-on-a-chip' concept into a comprehensive 'organismoid theory'.
• To outline principles for creating and maintaining individual human body equivalents in vitro.
• To explore the application of organismoids in personalized therapy selection and disease modeling.

Main Methods:

• Development of organismoids: minute, physiological in vitro equivalents of a mature human body.
• Mimicking human ontogenesis through an artificially shortened process of self-assembly.
• Maintaining homeostasis in organismoids over extended periods and inducing diseases for study.

Main Results:

• Organismoids can be created to reflect individual human physiology and morphology.
• Methods are proposed for maintaining healthy organismoids and inducing disease states.
• The potential for organismoids to predict personalized therapeutic responses is discussed.

Conclusions:

• The organismoid theory offers a novel platform for precise, personalized medicine.
• This approach could significantly impact healthcare, particularly in the adoption of personalized T-cell therapies.
• Organismoids represent a significant advancement in in vitro human body modeling for predictive health applications.