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Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

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Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
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Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

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Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
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Related Experiment Video

Updated: Oct 18, 2025

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
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Postoperative Ileus: Comparative Pathophysiology and Future Therapies.

Emily A Hellstrom1, Amanda L Ziegler1, Anthony T Blikslager1

  • 1Department of Clinical Sciences, North Carolina State University, Raleigh, NC, United States.

Frontiers in Veterinary Science
|September 30, 2021
PubMed
Summary

Postoperative ileus (POI) significantly impacts patient survival after surgery, especially in horses. Understanding its complex pathophysiology offers new therapeutic targets for this common complication.

Keywords:
barrier functionenteric glia and neuronsequineintestinemicrobiotasurgery

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Area of Science:

  • Veterinary Surgery
  • Gastroenterology
  • Pathophysiology

Background:

  • Postoperative ileus (POI) is a common complication following surgery, characterized by decreased gastrointestinal motility.
  • POI significantly impacts patient outcomes, with a high mortality rate (37.5%) in horses undergoing small intestinal resection.
  • The pathophysiology involves neurogenic and inflammatory phases, influenced by perioperative care, including opioid use, fluid therapy, and electrolyte balance.

Purpose of the Study:

  • To review the current understanding of postoperative ileus (POI) pathophysiology.
  • To identify potential future therapeutic targets for POI prevention and treatment.

Main Methods:

  • Literature review of POI pathophysiology and current management strategies.
  • Analysis of the roles of gastrointestinal microbiota, intestinal barrier function, inflammation, and enteric glial cells.

Main Results:

  • Current therapies for POI, including early feeding, NSAIDs, and lidocaine, show variable success.
  • Optimal management of POI remains controversial and requires further investigation.
  • Emerging research highlights the importance of the gut microbiota, barrier function, inflammatory response, and enteric glial cells.

Conclusions:

  • Further research into the gastrointestinal microbiota, intestinal barrier function, inflammatory pathways, and enteric glial cells is crucial.
  • These factors represent potential targets for novel preventative and therapeutic strategies for POI.
  • Improved understanding may lead to better management of this significant surgical complication.