Related Experiment Video

Updated: Oct 18, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.1K

Antimicrobial stewardship program in pediatric medicine

Varvara Probst1, Florinda Islamovic1, Ayesha Mirza1

  • 1University of Florida College of Medicine Jacksonville FL USA.

Pediatric Investigation
|September 30, 2021
PubMed

Insights

Antimicrobial stewardship programs (ASPs) are crucial for improving antimicrobial prescribing in pediatrics, reducing resistance and healthcare costs. Challenges remain, but ASPs are vital for global healthcare strategies.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance
  • Healthcare Management

Background:

  • Antimicrobial resistance (AMR) poses a significant global threat, exacerbated by inappropriate antimicrobial use in healthcare, including pediatrics.
  • Antimicrobial stewardship programs (ASPs) are essential multidisciplinary initiatives to optimize antimicrobial prescribing and combat AMR.

Purpose of the Study:

  • To review the core elements of pediatric antimicrobial stewardship programs (ASPs).
  • To evaluate the impact of implemented ASPs on pediatric healthcare outcomes.
  • To identify and discuss existing challenges in pediatric ASP implementation.

Main Methods:

  • This study is a narrative review of existing literature on pediatric ASPs.
  • The review synthesizes published reports on the effectiveness and challenges of ASPs in pediatric settings.

Main Results:

  • Implemented pediatric ASPs demonstrate improvements in antimicrobial utilization, reduced drug resistance, and decreased treatment failures.
  • ASPs contribute to minimizing adverse clinical outcomes, lowering healthcare costs, and reducing hospital length of stay.
  • Optimization of diagnostic strategies is another key benefit of effective pediatric ASPs.

Conclusions:

  • Pediatric ASPs are critical for mitigating antimicrobial resistance and improving patient outcomes.
  • Despite demonstrated benefits, barriers to successful pediatric ASP implementation persist.
  • Further efforts are needed to overcome challenges and enhance the widespread adoption of pediatric ASPs.

Keywords:
Antimicrobial resistanceAntimicrobial stewardshipInfection controlPediatrics

More Related Videos

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.2K
Quantifying the Effects of Antimicrobials on In vitro Biofilm Architecture using COMSTAT Software06:18

Quantifying the Effects of Antimicrobials on In vitro Biofilm Architecture using COMSTAT Software

Published on: December 14, 2020

3.6K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
37
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
35
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
37
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
31
Antimicrobial Proteins01:23

Antimicrobial Proteins

Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
10.0K
Antibiotic Selection00:57

Antibiotic Selection

Overview
56.6K