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Use of Capillary Electrophoresis Immunoassay to Search for Potential Biomarkers of Amyotrophic Lateral Sclerosis in Human Platelets
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Serum programmed cell death proteins in amyotrophic lateral sclerosis

David R Beers1, Weihua Zhao1, Jason R Thonhoff1

  • 1Peggy and Gary Edwards ALS Laboratory, Department of Neurology, Houston Methodist Neurological Institute, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX, USA.

Brain, Behavior, & Immunity - Health
|September 30, 2021
PubMed
Summary

Soluble programmed cell death proteins (sPD-1, sPD-L1, sPD-L2) were elevated in amyotrophic lateral sclerosis (ALS) patients. These elevated levels correlate with disease burden, suggesting a role for peripheral inflammation in ALS.

Keywords:
Amyotrophic lateral sclerosisCancerImmune regulatory checkpoint pathwaysInflammationNeurodegenerationNeuromuscular diseaseProgram cell death proteins

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