Related Experiment Video
Updated: Oct 18, 2025

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
Medicinal cannabis in the treatment of chronic pain
Luke A Henderson1, Vicki Kotsirilos2, Elizabeth A Cairns3
1PhD, Professor, School of Medical Sciences (Neuroscience), University of Sydney, Sydney, NSW; Brain and Mind Centre, University of Sydney, Sydney, NSW.
Background:
Chronic pain is a major health issue, adversely affecting millions of Australians and costing billions of dollars annually. Current pharmaceutical treatments may be limiting, and in some cases ineffective, while carrying substantial liabilities. Medicinal cannabis is an increasingly popular, albeit controversial, alternative.
Objective:
The aim of this article is to briefly review the scientific evidence related to medicinal cannabis for the treatment of chronic pain and update physicians on relevant issues and optimal prescribing practices.
Discussion:
To date, >130,000 medicinal cannabis approvals have been issued in Australia, mostly by general practitioners, with approximately 65% of these to treat chronic non-cancer pain. Available products deliver Δ9-tetrahydrocannabinol (THC) and/or cannabidiol (CBD). Despite robust supportive data from animal models, current clinical trial evidence for THC and CBD efficacy in chronic pain is incomplete. In their prescribing decisions, doctors must balance patient demand and curiosity with caution regarding potential risks and limited efficacy.
Related Concept Videos
Analgesia and Pain Management
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Chronic Pancreatitis II: Collaborative Care
Assessment:
Opioid Analgesics: Synthetic and Semisynthetic Opioids
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

