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Updated: Oct 18, 2025

High-throughput Screening of Chemical Compounds to Elucidate Their Effects on Bacterial Persistence
Published on: February 23, 2021
Detecting Persister Awakening Determinants
Dorien Wilmaerts1,2, Jan Michiels3,4, Natalie Verstraeten1,2
1VIB-KU Leuven Center for Microbiology, VIB, Leuven, Belgium.
Abstract:
For long, persistence research has focused primarily on disentangling mechanisms of persister state entry. Due to the rapid advances in the field of single-cell techniques and newly obtained insights in the persister phenotype, studying persister awakening has been unlocked and it has gained much interest in the scientific community. However, a framework on how this research should be conducted is currently lacking. Therefore, we here present a method to detect and validate genes important for persister awakening.
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