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Microsampling with a Solid-Phase Extraction Cartridge: Storage and Online Mass Spectrometry Analysis.

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A novel syringe-based solid-phase extraction (SPE) cartridge enables remote biofluid microsampling, storage, and direct analysis. This method ensures analyte stability for over a year, offering a versatile alternative for bioanalysis.

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Area of Science:

  • Analytical Chemistry
  • Biomedical Science
  • Forensic Science

Background:

  • Conventional biofluid microsampling methods face challenges in storage and shipment.
  • Need for stable, easy-to-use techniques for remote sample collection and analysis.

Purpose of the Study:

  • Introduce a novel syringe-based solid-phase extraction (SPE) cartridge for remote biofluid collection.
  • Evaluate its utility for storage, shipment, and direct online electrospray ionization mass spectrometry (ESI-MS) analysis.

Main Methods:

  • Developed a syringe-based SPE cartridge packed with sorbents.
  • Used for collecting small volumes (<20 μL) of biofluids (blood, plasma, serum, urine).
  • Analyzed stored dried samples directly using ESI-MS without chromatography.

Main Results:

  • Maintained analyte stability (e.g., diazepam) for over a year at room temperature.
  • Achieved excellent accuracy, precision, and sensitivity for illicit drug analysis.
  • Demonstrated low detection limits (26 pg/mL in urine, 140 pg/mL in plasma) without chromatography.

Conclusions:

  • The syringe-based SPE cartridge is a viable alternative to conventional microsampling techniques.
  • Offers advantages in analyte stability, ease of operation, versatility, and analytical speed.
  • Enables efficient remote biofluid collection and direct MS analysis.