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Aggressive (malignant?) epithelial odontogenic ghost cell tumor.

G L Ellis, B M Shmookler

Oral Surgery, Oral Medicine, and Oral Pathology

|May 1, 1986

Summary

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The epithelial odontogenic ghost cell tumor (EOGCT) is a rare neoplasm that can mimic calcifying odontogenic cysts (COC). This study reports three aggressive EOGCT cases, suggesting malignant potential despite no known metastasis.

Area of Science:

Oral pathology
Odontogenic neoplasms
Neoplasm classification

Background:

The calcifying odontogenic cyst (COC) is a recognized entity in oral pathology.
A distinct odontogenic neoplasm shares histologic similarities with COC and is often misdiagnosed.
The term epithelial odontogenic ghost cell tumor (EOGCT) is proposed for this neoplasm.

Observation:

Three cases of EOGCT exhibited aggressive growth patterns.
Histologic features suggested a potential for malignancy in these EOGCT cases.
Two cases occurred in the maxilla, and one in the mandible, with varied clinical presentations.

Findings:

None of the reported EOGCT cases have metastasized.
One EOGCT was diagnosed 9 years after typical COC removal.

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Another EOGCT case showed rapid recurrence post-excision.

Implications:

EOGCT may represent a distinct entity with malignant potential, requiring careful distinction from COC.
Further research is needed to fully understand the behavior and classification of EOGCT.
Recognition of aggressive features in EOGCT is crucial for appropriate patient management and treatment planning.