End-Point Immobilization of Heparin on Electrospun Polycarbonate-Urethane Vascular Graft

There is a tremendous clinical need for synthetic vascular grafts either for bypass procedure or vascular access during hemodialysis. However, currently, there is no small-diameter vascular graft commercially available to meet long-term patency requirement due to frequent thrombus formation and intimal hyperplasia. This chapter describes the fabrication of electrospun small-diameter polycarbonate-urethane (PCU) vascular graft with a biomimetic fibrous structure. Additionally, the surface of the vascular graft is aminated via plasma treatment for the subsequently end-point heparin immobilization to enhance antithrombosis property.