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Published on: October 4, 2019
Expression pattern of MRPS18 family genes in gliomas
L M Kovalevska1, T A Malysheva2, S S Kalman1
1R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NASU, Kyiv 03022, Ukraine.
Aim:
To assess expression patterns of MRPS18 family genes in glioblastoma tissues and glioma cell lines.
Materials And Methods:
Expression of MRPS18 family genes was analyzed by quantitative polymerase chain reaction in glioma cell lines and glioblastoma specimens. A bioinformatic analysis of the publicly available data on the expression of these genes was also provided.
Results:
The genes of MRPS18 family show different expression patterns in glioblastomas and glioma cell lines. The highest levels of expression were found for MRPS18-2 at mRNA and protein levels in both glioblastomas and glioma cell lines; the lowest - for MRPS18-1 at mRNA level.
Conclusions:
The elevated levels of relative expression of the MRPS18-2 gene are characteristic for glioma tumor tissues and cell lines.
