Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

696
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
696
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.3K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.3K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

47
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
47
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

1.0K
The pathophysiology of pneumonia involves the following steps:
1.0K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

48
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
48

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PD-L1 deletion or blockade regulate macrophage antigen presentation and checkpoint molecule surface levels.

bioRxiv : the preprint server for biology·2026
Same author

Loss of the kinases TBK1 and IKKε sensitizes target cancer cells to T cell killing through an IFN-γ-mediated inflammatory death program.

Science signaling·2026
Same author

Respiratory Microbiome Remodeling in Aging: Implications for Immunosenescence and Therapeutic Intervention.

Immune network·2026
Same author

An early protective effect of IL-9 in murine systemic lupus erythematosus.

ImmunoHorizons·2026
Same author

Revised Adaptive Immune Receptor Data in the Immune Epitope Database.

bioRxiv : the preprint server for biology·2026
Same author

IL15-mediated crosstalk between LSECs and CD8⁺ tissue-resident memory T cells drives alcohol-associated hepatitis.

Hepatology communications·2026

Related Experiment Video

Updated: Oct 18, 2025

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.3K

Immune signatures underlying post-acute COVID-19 lung sequelae.

I S Cheon1,2, C Li1,2, Y M Son1,2

  • 1Division of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Science Immunology
|September 30, 2021
PubMed
Summary

Long COVID survivors show lasting immune changes in the lungs, with specific T cell responses linked to impaired lung function after severe COVID-19 pneumonia. These findings offer insights into chronic respiratory symptoms.

More Related Videos

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.4K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

575

Related Experiment Videos

Last Updated: Oct 18, 2025

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
14:48

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury

Published on: March 21, 2021

5.3K
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.4K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

575

Area of Science:

  • Immunology
  • Pulmonology
  • Virology

Background:

  • Severe COVID-19 pneumonia can lead to long-term lung damage (pulmonary sequelae).
  • The mechanisms and immune factors driving these chronic lung issues remain unclear.

Purpose of the Study:

  • To characterize the immune and pathophysiological traits in aged COVID-19 convalescents.
  • To correlate local and systemic immune profiles with lung function and imaging.

Main Methods:

  • High-dimensional characterization of immune and pathophysiological traits.
  • Analysis of local (lung) and systemic (blood) immune cell populations.
  • Single-cell transcriptomic analysis of respiratory CD8+ T cells.

Main Results:

  • Chronic lung impairment is associated with persistent respiratory immune alterations.
  • Functional SARS-CoV-2-specific memory T and B cells are more abundant in the lungs than in blood.
  • Dysregulated respiratory CD8+ T cell responses correlate with reduced lung function post-COVID-19.

Conclusions:

  • Specific CD8+ T cell subsets in the lungs may contribute to persistent tissue damage after COVID-19.
  • Identified immune traits may explain lung sequelae in older individuals after SARS-CoV-2 pneumonia.
  • Findings may inform treatments for chronic COVID-19 symptoms.