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Complete Genome Sequences of Enterovirus D68 Clade A and D Strains in the Philippines

Michiko Okamoto1, Masahiro Sakamoto1, Clyde Dapat1

  • 1Department of Virology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Microbiology Resource Announcements
|September 30, 2021
PubMed

Insights

Researchers sequenced 16 enterovirus D68 strains from children in the Philippines. This genomic data aids in tracking the virus and understanding its evolution.

Area of Science:

  • Virology
  • Genomics
  • Epidemiology

Background:

  • Enterovirus D68 (EV-D68) is a significant respiratory pathogen.
  • Clades A and D are known genetic lineages of EV-D68.
  • Respiratory illnesses in children necessitate ongoing viral surveillance.

Purpose of the Study:

  • To determine the complete genome sequences of EV-D68 strains.
  • To analyze genetic diversity within EV-D68 clades A and D.
  • To provide genomic data for future epidemiological studies in the Philippines.

Main Methods:

  • Whole genome sequencing of 16 EV-D68 strains.
  • Detection of viruses in nasopharyngeal swabs.
  • Bioinformatic analysis of sequence data.

Main Results:

  • Complete genome sequences were obtained for 4 clade A and 12 clade D EV-D68 strains.
  • The study identified specific EV-D68 strains circulating in the Philippines.
  • Sequence data provides a baseline for evolutionary analysis.

Conclusions:

  • The generated genome sequences are valuable resources for monitoring EV-D68.
  • This data supports ongoing surveillance of viral evolution and epidemiology.
  • Understanding circulating strains is crucial for public health interventions.

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