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Related Concept Videos

Whole Body Regeneration01:33

Whole Body Regeneration

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Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
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Overview of Regeneration and Repair01:19

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Regeneration Roadmap: database resources for regenerative biology.

Wang Kang1,2,3,4, Tong Jin2,5,4, Tao Zhang2,5,4

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

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Summary

Researchers developed Regeneration Roadmap, a comprehensive database for regeneration studies. This resource aids in understanding aging and damage repair by centralizing millions of data entries across species and tissues.

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Area of Science:

  • Regenerative biology
  • Aging research
  • Bioinformatics

Background:

  • Regeneration is crucial for development and repair, but capacity declines with age.
  • Promoting regeneration is a strategy for anti-aging interventions.
  • Existing regeneration data is fragmented, lacking a centralized, standardized resource.

Purpose of the Study:

  • To create a comprehensive, open database for regeneration research data.
  • To systematically collect and standardize diverse data types, including omics data.
  • To facilitate exploration of regeneration mechanisms across species and tissues.

Main Methods:

  • Compiled over 2.38 million data entries.
  • Integrated data from 11 species and 36 tissues.
  • Included regeneration-related genes, transcriptomics, epigenomics, and pharmacogenomics data.

Main Results:

  • Developed 'Regeneration Roadmap,' a centralized database.
  • Data entries cover genes, bulk and single-cell transcriptomics, epigenomics, and pharmacogenomics.
  • The database enables exploration of gene regulation and expression in regeneration.

Conclusions:

  • Regeneration Roadmap is a valuable, long-awaited resource for the research community.
  • Provides convenient computing and visualization tools for analyzing regeneration data.
  • Publicly available at https://ngdc.cncb.ac.cn/regeneration/index to advance aging and repair research.