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Construction and bioapplications of aptamer-based dual recognition strategy
Ya Wang1, Xinlian Liu1, Longjie Wu1
1College of Public Health, Zhengzhou University, Zhengzhou, 450001, China.
Biosensors & Bioelectronics
|September 30, 2021
Summary
Dual aptamer strategies enhance detection sensitivity and selectivity for biomarkers, pathogens, and cancer cells. This review explores their applications in diagnostics, therapeutics, and cell receptor imaging for precision medicine.
Area of Science:
- Biotechnology
- Analytical Chemistry
- Biomedical Engineering
Background:
- Single-molecule recognition strategies have limitations in sensitivity and selectivity.
- Aptamers offer unique advantages as recognition elements in biosensing.
- Dual recognition strategies can overcome single-molecule limitations.
Purpose of the Study:
- To review the construction and applications of aptamer-based dual recognition strategies.
- To highlight the use of dual aptamers and aptamer-other recognition element cooperation.
- To discuss challenges and future directions in the field.
Main Methods:
- Systematic review of literature on aptamer-based dual recognition strategies.
- Analysis of applications in biomarker detection, pathogen identification, and cancer cell targeting.
- Examination of roles in disease treatment, cell receptor imaging, and functional regulation.
Main Results:
- Dual aptamer strategies significantly improve sensitivity and selectivity in various bioanalytical applications.
- Cooperation with other recognition elements further enhances performance.
- Applications span diagnostics, therapeutics, and advanced cell imaging.
Conclusions:
- Aptamer-based dual recognition strategies offer versatile and effective solutions for complex bioanalytical challenges.
- These strategies are crucial for advancing precision medicine through improved diagnostics and targeted therapies.
- Further research is needed to address existing challenges and expand applications.
