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FGF/FGFR signaling: From lung development to respiratory diseases
Lehe Yang1, Feng Zhou1, Dandan Zheng1
1Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang 325000, China.
Cytokine & Growth Factor Reviews
|October 1, 2021
Summary
Fibroblast growth factor/receptor (FGF/FGFR) signaling is crucial for lung development and diseases like cancer and fibrosis. This review covers recent advances in FGF/FGFR roles in lung pathophysiology.
Area of Science:
- Cellular biology
- Molecular biology
- Developmental biology
Background:
- Fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling regulates key cellular processes like proliferation, differentiation, migration, survival, and metabolism.
- The lung's complex structure is vital for oxygen exchange, with airways terminating in alveoli.
- FGF/FGFR signaling is implicated in lung development and the pathogenesis of numerous human respiratory diseases.
Purpose of the Study:
- To review recent advancements in understanding FGF/FGFR signaling pathways.
- To highlight the role of FGF/FGFR signaling in human lung development.
- To explore the involvement of FGF/FGFR signaling in various respiratory diseases.
Main Methods:
- Literature review of recent research on FGF/FGFR signaling.
- Analysis of studies focusing on lung development and respiratory disease pathogenesis.
- Synthesis of findings related to FGF/FGFR's regulatory functions.
Main Results:
- FGF/FGFR signaling is essential for normal lung morphogenesis and function.
- Dysregulation of FGF/FGFR signaling contributes to the development of lung cancer, acute lung injury (ALI), pulmonary arterial hypertension (PAH), chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis.
- Specific FGF/FGFR pathways are implicated in the distinct pathologies of these diseases.
Conclusions:
- FGF/FGFR signaling represents a critical regulator in both lung development and disease.
- Targeting FGF/FGFR pathways holds therapeutic potential for a range of respiratory conditions.
- Further research into FGF/FGFR signaling mechanisms is warranted for novel treatment strategies.
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