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Published on: February 12, 2017
Immunonutritional Indices in Non-small-cell Lung Cancer Patients Receiving Adjuvant Platinum-based Chemotherapy
Taichi Matsubara1, Fumihiko Hirai2, Masafumi Yamaguchi2
1Department of Thoracic Surgery, Kitakyushu Municipal Medical Center, Fukuoka, Japan taichi.m0930@gmail.com.
Background/Aim:
Adjuvant platinum-based chemotherapy (APC) has been the standard of care for patients with non-small-cell lung cancer (NSCLC) who have undergone complete pulmonary resection. This study analyzed the clinical and prognostic significance of immunonutritional indices in NSCLC patients receiving APC.
Patients And Methods:
We retrospectively reviewed 110 patients from 2008 to 2016. Three immunonutritional indices were calculated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI).
Results:
The median age was 64 years, and 66 patients were males. Each index showed a significant correlation with primary tumor length. NLR and PLR were significantly correlated with vascular invasion. Prognostic analyses revealed that each index was significantly correlated with postoperative recurrence-free survival (RFS) and overall survival (OS). On multivariate analyses, PNI was an independent predictor of RFS and OS.
Conclusion:
Host immunonutritional status may have a significant effect on the postoperative prognosis of NSCLC in patients receiving APC.
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