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Related Experiment Video

Updated: Oct 18, 2025

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

Exploring the Relationship Between Objective Pupillometry Metrics and Midline Shift.

Kathryn Giamarino, Robert Blessing, Christopher Boelter

The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses

|October 1, 2021

Summary

This summary is machine-generated.

Objective pupillometry, using metrics like the Neurological Pupil Index (NPi), shows significant correlations with midline shift (MLS). This supports its role in detecting early neurological changes for timely interventions.

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Last Updated: Oct 18, 2025

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

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Published on: November 26, 2019

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Published on: March 3, 2023

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer

Published on: January 29, 2020

Area of Science:

Neurology
Ophthalmology

Background:

Pupillary examinations can indicate intracranial pathology.
Objective pupillometry is best practice but lacks clinical guidelines due to inconsistent findings.
This study aimed to add evidence by exploring pupillometry metrics and midline shift.

Purpose of the Study:

To investigate the relationship between objective pupillometry metrics and midline shift (MLS).

Main Methods:

Retrospective chart review of pupillometer data.
Correlation of midline shift with Neurological Pupil Index (NPi), pupil size, and anisocoria.
Statistical analysis using Spearman ρ.

Main Results:

Significant positive correlations found between right pupil NPi and anisocoria with MLS.
Significant negative correlations observed between left pupil NPi and pupil size with MLS.
41 patients included in the analysis.

Conclusions:

Objective pupillometry is valuable for detecting early neurological changes.
Findings align with previous studies, reinforcing pupillometry's role in neurological assessments.
Supports the use of objective pupillometry for potentially lifesaving interventions.