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Inflammatory Mechanism and Clinical Implication of Asthma in COVID-19

Vasa Adi Wisnu Wardana1,2, Alfian Nur Rosyid1,2

  • 1Airlangga University, Surabaya, Indonesia.

Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
|October 1, 2021
PubMed

Insights

Asthma patients may have different susceptibility to COVID-19 due to reduced ACE2 receptor expression. This review explores the link between asthma pathophysiology and COVID-19 risk.

Area of Science:

  • Respiratory Medicine
  • Infectious Diseases
  • Public Health

Background:

  • Asthma is a chronic respiratory inflammatory disease with increasing global prevalence, particularly in children.
  • Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, became a pandemic in March 2020.
  • Individuals with asthma often experience more severe outcomes from respiratory viral infections.

Purpose of the Study:

  • To discuss the pathophysiology of asthma and COVID-19.
  • To analyze the susceptibility of asthma patients to contracting COVID-19.
  • To explore the role of ACE2 receptor expression in the interaction between asthma and SARS-CoV-2.

Main Methods:

  • Literature review and synthesis of existing research on asthma and COVID-19.
  • Analysis of the mechanisms of SARS-CoV-2 entry via ACE2 receptors.
  • Examination of factors influencing ACE2 receptor expression in asthma patients.

Main Results:

  • Asthma is recognized as a risk factor for COVID-19, though study results vary.
  • SARS-CoV-2 uses the ACE2 receptor for cellular entry.
  • Asthma patients exhibit reduced ACE2 receptor expression, potentially influenced by asthma therapies.

Conclusions:

  • Understanding the interplay between asthma and COVID-19 pathophysiology is crucial.
  • Reduced ACE2 expression in asthma may influence susceptibility and disease severity.
  • Further research is needed to clarify the precise relationship and clinical implications.

Keywords:
ACE2AsthmaCOVID-19

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