Prevalence of Antimicrobial Resistant of Vibrio parahaemolyticus Isolated from Diarrheal Patients - Six PLADs, China,

Haihong Han1, Sara M Pires2, Johanne Ellis-Iversen3

  • 1National Health Commission Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (No.2019RU014), China National Center for Food Safety Risk Assessment, Beijing, China.

China CDC Weekly
|October 1, 2021
PubMed
Abstract

Insights

Vibrio parahaemolyticus exhibits high resistance to cefazolin and ampicillin but remains susceptible to most other antibiotics. This study highlights significant variations in antimicrobial resistance patterns.

Area of Science:

  • Microbiology
  • Antimicrobial Resistance
  • Public Health

Background:

  • Vibrio parahaemolyticus (V. parahaemolyticus) often shows resistance to ampicillin and susceptibility to other antimicrobials.
  • Understanding antimicrobial resistance patterns is crucial for effective treatment and public health strategies.

Purpose of the Study:

  • To investigate the antimicrobial resistance profiles of V. parahaemolyticus in Chinese clinical settings.
  • To identify variations in resistance patterns based on regional, temporal, sexual, and source factors.

Main Methods:

  • Antimicrobial susceptibility testing was performed on V. parahaemolyticus isolates.
  • Resistance rates to various antibiotics, including cefazolin, ampicillin, and imipenem, were determined.
  • Multidrug resistance was assessed.

Main Results:

  • High resistance rates were observed for cefazolin (94.4%) and ampicillin (37.0%).
  • Resistance to 10 other antimicrobials, including imipenem, was below 3%.
  • Overall antimicrobial resistance was 95.1%, with 3.3% multidrug resistance, showing significant variations.

Conclusions:

  • V. parahaemolyticus in China displays significant resistance to specific antibiotics like cefazolin and ampicillin.
  • The study provides essential data for developing targeted public health interventions and antimicrobial stewardship programs.

Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
518
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
506
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
239