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Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain

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Labeling Aversive Memory Trace in Mouse Using a Doxycycline-inducible Expression System.

Jianyang Du¹, Erin E Koffman¹

¹Department of Biological Sciences, University of Toledo, Toledo, OH, USA.

|October 1, 2021

Summary

Researchers developed a new method to label neurons involved in memory traces, also known as memory engrams. This technique aids in understanding brain circuits and how memories are physically stored.

Keywords:

AAV9-TRE-mCherry Aversive memory Doxycycline-inducible expression system Memory trace TetTag Fos-tTA mouse

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Area of Science:

Neuroscience
Molecular Biology
Cognitive Science

Background:

Memory traces (engrams) are physical substrates of memory storage in the brain.
Specific neuronal populations are associated with memory traces.
Understanding neuronal circuits is crucial for memory research.

Purpose of the Study:

To introduce a novel method for labeling neurons constituting a memory trace.
To facilitate the study of neuronal circuits involved in memory formation and retrieval.

Main Methods:

Utilized a doxycycline-inducible expression system.
Developed a protocol to label specific neurons associated with an original memory trace.

Main Results:

Successfully established a system to label memory-associated neurons.
The protocol allows for targeted identification of neuronal populations involved in memory.

Conclusions:

This method provides a valuable tool for investigating the neural basis of memory.
The findings advance our understanding of how memory traces are physically represented in the brain.