Managing Endocrine Disorders in Adults After Hematopoietic Stem Cell Transplantation

Area of Science:

• Endocrinology
• Hematology
• Oncology

Background:

• Hematopoietic stem cell transplantation (HSCT) is a curative option for various diseases.
• Improved survival post-HSCT shifts focus to long-term complications.
• Endocrine disorders are common late effects after HSCT.

Purpose of the Study:

• To review recent literature on endocrine late effects post-HSCT.
• To provide practical guidance on screening and managing these conditions.
• To highlight the need for evidence-based guidelines.

Main Methods:

• Literature review of endocrine disorders following HSCT.
• Focus on dyslipidemia, diabetes, thyroid disorders, osteoporosis, and hypogonadism.
• Outline of mechanisms, monitoring, and management strategies.

Main Results:

• Endocrine disorders are prevalent late effects of HSCT.
• Specific recommendations for managing dyslipidemia, diabetes, thyroid disorders, osteoporosis, and hypogonadism are provided.
• Growing data underscore the need for further research.

Conclusions:

• Effective screening and management of endocrine late effects are vital post-HSCT.
• Addressing these complications can reduce morbidity and mortality.
• Future research should focus on developing evidence-based guidelines for endocrine care after HSCT.