Related Experiment Video

Updated: Oct 18, 2025

Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease
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Bone Marrow Transplantation Platform to Investigate the Role of Dendritic Cells in Graft-versus-Host Disease

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Current Status and Future Directions in Graft-Versus-Host Disease Prevention Following Allogeneic Blood and Marrow

Cosmin Tegla1, Jun Choi1, Maher Abdul-Hay2

  • 1Division of Hematology and Medical Oncology, New York University Langone Health, New York, NY, USA.

Clinical Hematology International
|October 1, 2021
PubMed

Insights

Graft-versus-host disease (GvHD) hinders blood and marrow transplantation success. Current prevention relies on calcineurin inhibitors, but post-transplant cyclophosphamide offers a promising alternative, enabling novel GvHD-free combinations.

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Graft-versus-host disease (GvHD) is a major complication of blood and marrow transplantation.
  • It limits the curative potential of transplantation for various blood disorders.

Purpose of the Study:

  • To review current strategies for GvHD prevention.
  • To highlight emerging and promising GvHD prevention combinations.

Main Methods:

  • Review of existing literature on GvHD prophylaxis.
  • Analysis of current and novel GvHD prevention regimens.

Main Results:

  • Calcineurin inhibitor (CNI)-based regimens are the standard for GvHD prevention.
  • Post-transplant cyclophosphamide is an emerging alternative and key component in CNI-free strategies.

Conclusions:

  • GvHD remains a significant challenge in transplantation.
  • Innovative GvHD prevention strategies, including CNI-free approaches, are under development and show promise.

Keywords:
Calcineurin inhibitorsGvHD preventionPost-transplant cyclophosphamidemTOR inhibitors

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