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Updated: Oct 18, 2025

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Giant, symptomatic mixed vascular malformation containing a cavernoma, developmental venous anomaly, and capillary
Wendy Gaztanaga1, Evan Luther2, David McCarthy2
1Department of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA. w.gaztanaga@med.miami.edu.
Abstract:
Intracranial mixed vascular malformations (MVMs) are defined as any combination of a developmental venous anomaly (DVA), cerebral cavernous malformation (CCM), capillary telangiectasia (CTG), or arteriovenous malformation (AVM) within a single, contiguous lesion. However, most MVMs described in the literature contain only 2 pathologically discrete malformations; juxtaposition of 3 or more abnormalities in a single lesion remains exceedingly rare. We present the case of a 19-month-old female with new onset focal seizures and a 4-cm right basal ganglia lesion initially believed to be an embryonal neoplasm. She subsequently underwent gross total resection (GTR) of the lesion via a transsylvian-transinsular approach. Intraoperatively, the lesion appeared to be heterogenous and highly vascular, with areas of purplish-gray friable tissue. Pathology confirmed the lesion to be a MVM containing a CCM, CTG, and a DVA. This appears to be the first reported case of such a lesion confirmed on pathology in the literature.
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