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Updated: Oct 18, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
How Does Fasting Affect Cognition? An Updated Systematic Review (2013-2020)
Erik M Benau1, Amanda Makara2, Natalia C Orloff2
1SUNY Old Westbury, Old Westbury, NY, USA.
Purpose Of Review:
The goal of this review was to provide an update on the literature examining how voluntary, temporary abstention from eating impacts cognitive function.
Recent Findings:
We evaluated peer-reviewed articles published between August 2013 and January 2021 that assessed adults, included a measure of cognitive functioning with neutral stimuli, and compared individuals in a fasted state to individuals in a fed state (either within- or between-subject designs). Nineteen articles (21 studies) met inclusion criteria. Sample sizes, fasting methods, and tasks varied across studies. Review of studies indicated that fasting was associated with deficits in cognitive functioning; few studies indicated a benefit in cognitive functioning following a single voluntary fast. The heterogeneity and rarity of available studies limits the conclusions that can be drawn. Several crucial psychosocial and sociodemographic moderators remain unexplored. Recommendations for future work are discussed.
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