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Updated: Oct 18, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
Chemical Probes for Histamine Receptor Subtypes
Markus Falkenstein1, Milica Elek1, Holger Stark2
1Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Duesseldorf, Germany.
Abstract:
Ligands with different properties and different selectivity are highly needed for in vitro and in vivo studies on the (patho)physiological influence of the chemical mediator histamine and its receptor subtypes. A selection of well-described ligands for the different receptor subtypes and different studies is shown with a particular focus on affinity and selectivity. In addition, compounds with radioactive or fluorescence elements will be presented with their beneficial use for other species or different investigations.
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