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Updated: Oct 18, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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An evaluation of KBP-5074 in advanced chronic kidney disease with uncontrolled hypertension

Bertram Pitt1, Frederic Jaisser2, George Bakris3

  • 1Department of Medicine, University of Michigan School of Medicine, Ann Arbor, USA.

Expert Opinion on Investigational Drugs
|October 1, 2021
PubMed

Insights

Resistant hypertension in advanced chronic kidney disease (CKD) poses risks. A new non-steroidal MRA, KBP-5074, shows promise for treating this condition without causing hyperkalemia.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Resistant hypertension (RH) is common in advanced chronic kidney disease (CKD), increasing cardiovascular and renal risks.
  • Current steroidal mineralocorticoid receptor antagonists (MRAs) are limited by hyperkalemia risk in CKD patients.
  • KBP-5074 is a novel non-steroidal MRA designed to treat RH in CKD without hyperkalemia.

Purpose of the Study:

  • To review current RH treatment in stage 3B/4 CKD.
  • To explore limitations of steroidal MRAs.
  • To evaluate the potential of KBP-5074 in this patient population.

Main Methods:

  • Overview of steroidal MRA limitations in CKD.
  • Exploration of emerging data on non-steroidal MRAs.
  • Focus on KBP-5074's applicability.

Main Results:

  • KBP-5074 demonstrated clinical efficacy in a Phase 2b trial.
  • The novel non-steroidal MRA was safe for treating RH in stage 3B/4 CKD.
  • No hyperkalemia-related adverse events were reported.

Conclusions:

  • KBP-5074 offers a potential new treatment for RH in stage 3B/4 CKD.
  • This non-steroidal MRA may improve outcomes in patients at high risk for CVD and CKD progression.
  • KBP-5074 addresses an unmet need for safe and effective RH treatment in CKD.
Abstract

Keywords:
Chronic kidney diseaseKBP-5074eplerenonehyperkalemiamineralocorticoid receptor antagonistresistant hypertensionspironolactoneuncontrolled hypertension

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