High cortisol and the risk of Alzheimer disease: A protocol for systematic review and meta-analysis
Zhuang Yao1, Bin Liu2, Yueyang Wang3
1Department of Nursing, Jiamusi College of Heilongjiang University of Chinese Medicine, Heilongjiang, China.
Background:
Morning cortisol levels have been reported to be elevated among patients with Alzheimer disease (AD). We perform a protocol for systematic review and meta-analysis to assess morning central or peripheral cortisol levels in AD patients as compared with cognitively normal individuals.
Methods:
Studies were identified through systematic searches in August 2021 with no restrictions on date and time, language, and publication status using the following bibliographic databases: Embase, Medline, PubMed, Web of Science, Science Direct, and the Cochrane Library. Studies were identified using search terms related to cortisol, Alzheimer disease, and cognitive impairment. The study quality of included papers was evaluated using the "National Institutes of Health (NIH) quality assessment tool for observational cohort and cross-sectional studies." Statistical analyses were performed using Stata (version 14, StataCorp, College Station, TX).
Results:
The findings of this study will be submitted to peer-reviewed journals for publication.
Conclusion:
Morning cortisol was elevated in AD patients and may have diagnostic and prognostic values for AD.
More Related Videos
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
08:25Collecting Saliva and Measuring Salivary Cortisol and Alpha-amylase in Frail Community Residing Older Adults via Family Caregivers
Published on: December 18, 2013
Related Concept Videos
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Psychoneuroimmunology: Diabetes and Cancer
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Hypothalamic-Pituitary Axis
Alzheimer's Disease: Treatment
Stress and Mental Health
Individuals with depression often experience challenges in both their personal and professional...
