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Porous Silicon Microparticles for Delivery of siRNA Therapeutics
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Thermally induced silane dehydrocoupling on porous silicon nanoparticles for ultra-long-acting drug release
Ji Hyeon Oh1, Rae Hyung Kang1, Jaehoon Kim1
1Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea. dkim@khu.ac.kr.
Nanoscale
|October 1, 2021
Abstract:
Here, we report an ultra-long-acting drug release nano-formulation based on porous silicon nanoparticles (pSiNPs) that are prepared by thermally induced silane dehydrocoupling and lipid-coating. This robust formulation offers the ability to release an anticancer drug, for up to 2 weeks, in various biological environments; pH 7.4 buffer, cancer cells, and tumor xenograft model.

