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Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Kingella kingae Spondylodiscitis: Treatment Failure With Flucloxacillin
Aaron Keene1, Julie Creighton1, Trevor Anderson1
1From the Microbiology Department, Canterbury Health Laboratories, Christchurch, New Zealand.
Abstract:
Kingella kingae infections generally respond well to most beta-lactam antibiotics. We investigated an antibiotic treatment failure in a 3-year-old with K. kingae L3-4 spondylodiscitis. Her disease progressed even after 19 days of high-dose intravenous flucloxacillin. The clinical isolate did not produce a beta-lactamase and despite phenotypic testing and whole-genome sequencing, the mechanism of flucloxacillin resistance remains unknown.
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