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Updated: Oct 18, 2025
Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Selective Benzylic CH-Borylations by Tandem Cobalt Catalysis
Pradip Ghosh1, Roland Schoch2, Matthias Bauer2
1Dept. of Chemistry, University of Hamburg, Martin Luther King Pl 6, 20146, Hamburg, Germany.
Abstract:
Metal-catalyzed C-H activations are environmentally and economically attractive synthetic strategies for the construction of functional molecules as they obviate the need for pre-functionalized substrates and minimize waste generation. Great challenges reside in the control of selectivities, the utilization of unbiased hydrocarbons, and the operation of atom-economical dehydrocoupling mechanisms. An especially mild borylation of benzylic CH bonds was developed with the ligand-free pre-catalyst Co[N(SiMe3 )2 ]2 and the bench-stable and inexpensive borylation reagent B2 pin2 that produces H2 as the only by-product. A full set of kinetic, spectroscopic, and preparative mechanistic studies are indicative of a tandem catalysis mechanism of CH-borylation and dehydrocoupling via molecular CoI catalysts.
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