Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

1.5K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.5K
Inflammatory Response01:28

Inflammatory Response

12.3K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.3K
Inflammation01:38

Inflammation

56.2K
Overview
56.2K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

259
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
259
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

9.9K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
9.9K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

13.2K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial Orchestration of Skin Fibrosis by a CD8+ T cell-Myofibroblast Axis.

bioRxiv : the preprint server for biology·2026
Same author

Local gene editing of fibroblasts in tumors reveals a new cancer-associated fibroblast state.

The Journal of experimental medicine·2026
Same author

Computational discovery of precision therapeutics for hidradenitis suppurativa.

bioRxiv : the preprint server for biology·2026
Same author

CD38 expression by neonatal human naive CD4+ T cells shapes their distinct metabolic and tolerogenic properties.

The Journal of clinical investigation·2026
Same author

Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration.

Cell reports·2025
Same author

Layilin regulates Treg motility and suppressive capacity in skin.

eLife·2025

Related Experiment Video

Updated: Oct 18, 2025

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

16.1K

Tregs and inflammation-bring it on!

Victoire Gouirand1, Michael D Rosenblum1

  • 1Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

Science Immunology
|October 1, 2021
PubMed
Summary

Regulatory T cells can reverse established autoimmunity. These immune cells offer a promising therapeutic avenue for autoimmune diseases.

Area of Science:

  • Immunology
  • Autoimmunity

Background:

  • Autoimmune diseases involve the immune system attacking the body's own tissues.
  • Current treatments often suppress the entire immune system, leading to side effects.

Purpose of the Study:

  • To investigate the role of regulatory T cells in reversing established autoimmune conditions.
  • To explore the potential of regulatory T cells as a targeted therapy.

Main Methods:

  • Utilized mouse models of established autoimmune diseases.
  • Administered regulatory T cells to assess their therapeutic effects.
  • Monitored disease progression and immune cell populations.

Main Results:

  • Regulatory T cells successfully reversed clinical signs of established autoimmunity.

More Related Videos

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

24.4K
In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

20.8K

Related Experiment Videos

Last Updated: Oct 18, 2025

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

16.1K
Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

24.4K
In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

20.8K
  • Treatment with regulatory T cells restored immune tolerance.
  • Specific mechanisms of regulatory T cell action were identified.

    • Conclusions:

    • Regulatory T cells demonstrate potent restorative functions in established autoimmunity.
    • These findings support the development of regulatory T cell-based therapies for autoimmune disorders.