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Peripheral Airway Impairment and Dysanapsis Define Risk of Uncontrolled Asthma in Obese Asthmatic Children

Yela Jung1, Tiffany Jean2, Tricia Morphew3

  • 1Department of Medicine, University of California Irvine, Orange, Calif.

The Journal of Allergy and Clinical Immunology. in Practice
|October 1, 2021
PubMed

Insights

Obesity in children with asthma increases the risk of dysanapsis and peripheral airway impairment (PAI), leading to uncontrolled asthma. These airway issues are key factors in how obesity affects asthma severity.

Area of Science:

  • Pediatric Pulmonology
  • Obesity Research
  • Asthma Management

Background:

  • The link between childhood obesity and poor asthma outcomes requires further investigation.
  • Dysanapsis and peripheral airway impairment (PAI) are potential mediators in obese asthmatic children.

Purpose of the Study:

  • To assess how obesity impacts dysanapsis and PAI in children with asthma.
  • To determine if obesity, dysanapsis, and PAI contribute to uncontrolled asthma.

Main Methods:

  • Evaluated 206 children (4-18 years) with moderate-to-severe asthma.
  • Assessed the relationship between Body Mass Index (BMI) and dysanapsis/PAI.
  • Used generalized linear models to analyze the risk of uncontrolled asthma.

Main Results:

  • Overweight and obese children showed increased dysanapsis and PAI.
  • Obesity increased odds of dysanapsis by 2.32 (P=.04) and PAI varied by age (OR 2.09 to 54.14).
  • Dysanapsis and PAI were significant predictors of uncontrolled asthma, with odds increasing significantly with age.

Conclusions:

  • Overweight and obesity significantly elevate the risk of dysanapsis and PAI in children.
  • These airway abnormalities, influenced by age and gender, increase the likelihood of uncontrolled asthma.
Abstract

Keywords:
ChildrenDysanapsisImpulse oscillometryObesityPeripheral airway impairmentReactanceResistanceUncontrolled asthma

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