Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enabling time-aware treatment plan evaluation for clinical proton pencil beam scanning systems.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Multicentre dosimetry audit in the European randomized phase III study of neoadjuvant chemoradiotherapy using proton versus photon radiotherapy in locally advanced oesophageal cancer.

Physics and imaging in radiation oncology·2026
Same author

An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy.

Physics and imaging in radiation oncology·2026
Same author

Investigation of compact multi-layer ionization chamber detector designs for quality control of CBCT-based synthetic CTs for adaptive proton therapy.

Physics in medicine and biology·2025
Same author

Surface imaging to evaluate the dosimetric impact of breast deformations in proton and photon therapy for breast cancer.

Physics in medicine and biology·2025
Same author

Radiotherapy quality assurance in the PROTECT trial - a European randomised phase III-trial comparing proton and photon therapy in the treatment of patients with oesophageal cancer.

Acta oncologica (Stockholm, Sweden)·2025

Related Experiment Video

Updated: Oct 18, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K

Optimizing calibration settings for accurate water equivalent path length assessment using flat panel proton

Carmen Seller Oria1, Gabriel Guterres Marmitt1, Jeffrey Free1

  • 1Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, The Netherlands.

Physics in Medicine and Biology
|October 1, 2021
PubMed
Summary

Optimizing flat panel detector proton radiography (FP-PR) calibration improves water equivalent path length (WEPL) accuracy for proton therapy. Specific energy layer spacing and material thickness increments ensure precise range uncertainty detection.

Keywords:
adaptive proton therapycalibrationflat panel detectorproton radiographyrange uncertaintieswater equivalent path length

More Related Videos

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.2K
Calibration Procedures for Orthogonal Superposition Rheology
08:43

Calibration Procedures for Orthogonal Superposition Rheology

Published on: November 18, 2020

2.2K

Related Experiment Videos

Last Updated: Oct 18, 2025

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.4K
Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage 40-300 kV X-Ray Facilities

Published on: February 20, 2021

5.2K
Calibration Procedures for Orthogonal Superposition Rheology
08:43

Calibration Procedures for Orthogonal Superposition Rheology

Published on: November 18, 2020

2.2K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Image Analysis

Background:

  • Proton therapy's effectiveness is challenged by uncertainties in proton range.
  • Water equivalent path length (WEPL) assessment using flat panel detector proton radiography (FP-PR) offers a method for detecting range uncertainties.
  • Accurate WEPL measurements are crucial and depend heavily on FP-PR calibration parameters.

Purpose of the Study:

  • To establish an optimal calibration procedure for FP-PR to ensure high accuracy in WEPL measurements.
  • To investigate the impact of different calibration settings on WEPL accuracy.

Main Methods:

  • Simulated FP-PR calibration datasets using varying proton energies and water-equivalent material thicknesses.
  • Investigated parameters included energy layer spacing (ΔE) and material slab thickness increment (ΔX).
  • Calculated relative WEPL errors by comparing simulated FP-PR data with ground truth from ionization chamber simulations.

Main Results:

  • Large mean and standard deviations in WEPL accuracy were observed with large ΔE values (≥7 MeV).
  • WEPL images calibrated with ΔE ≤ 5 MeV and ΔX ≤ 5 mm achieved high accuracy.
  • This optimal calibration range yielded mean WEPL errors within ±0.5% and standard deviations around 1%.

Conclusions:

  • An optimal FP-PR calibration was established with 3 MeV ≤ ΔE ≤ 5 MeV and 2 mm ≤ ΔX ≤ 5 mm.
  • These calibration parameters enable feasible and practical high-accuracy WEPL measurements using FP-PR.
  • This optimized calibration holds potential for assisting online range verification quality control in proton therapy.