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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging
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Miniature 120-beam coherent combiner with 3D-printed optics for multicore fiber-based endoscopy
Optics Letters
|October 1, 2021
Summary
Researchers developed a compact, high-efficiency coherent beam with 3D-printed micro-optics for ultra-fast two-photon imaging. This miniaturized device enables minimally invasive nonlinear endoscopy.
Area of Science:
- Optics and Photonics
- Biomedical Engineering
- Medical Imaging
Background:
- Minimally invasive procedures require miniaturized imaging devices.
- Two-photon imaging offers high resolution but often needs bulky equipment.
- Integrating advanced optics into small form factors is challenging.
Purpose of the Study:
- To develop a high-efficiency, miniaturized coherent beam source.
- To integrate 3D-printed micro-optics with a fiber bundle for compact imaging.
- To enable ultra-fast two-photon imaging via a nonlinear endoscope.
Main Methods:
- Fabrication of a coherent beam with 3D-printed micro-optics.
- Integration of optics onto the tip of a multicore fiber bundle.
- Demonstration of the device within a miniaturized nonlinear endoscope.
Main Results:
- Achieved a high-efficiency, miniaturized, ultra-fast coherent beam.
- Successfully integrated micro-optics directly onto a fiber optic tip.
- Device footprint achieved was 180 µm in diameter.
- Enabled two-photon imaging with the compact endoscope.
Conclusions:
- The developed device is suitable for minimally invasive ultra-thin nonlinear endoscopy.
- This technology advances the potential for in-vivo high-resolution imaging.
- Miniaturized optics and coherent beams are key for next-generation endoscopic tools.

