Effect of insulin resistance on lung function in asthmatic children
Jagdish Prasad Goyal1, Prawin Kumar1, Chirag Thakur1
1Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Objectives:
Insulin resistance may be associated with impaired lung function. The objective of this study was to examine the relationship between insulin resistance and lung function in asthmatic children.
Methods:
We performed a cross-sectional study on asthmatic children aged 6-18 years at Tertiary Care Center, India. Fasting serum glucose and insulin levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) in 90 children. Lung function tests were performed. Spearman correlation was used to assess the relationship between insulin resistance and lung function. Linear regression was done to adjust the potential confounders.
Results:
Insulin resistance was present in 15.5% of patients. We found a statistically significant inverse relationship between HOMA-IR and spirometric parameters such as forced expiratory volume in 1 s/forced vital capacity ratio and forced expiratory flow between 25 and 75% on Spearman correlation. However, adjusted regression for age, gender, and body mass index showed no significant association of lung function parameters with HOMA-IR.
Conclusions:
Insulin resistance may be considered for the decline in lung function in asthmatic children.
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