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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Treatment of infections caused by multi-resistant microorganisms in hospital at home units
1Manuel Mirón-Rubio, Unidad de Hospitalización a Domicilio. Hospital Universitario de Torrejón. Spain. mmrubio@torrejonsalud.com.
Abstract:
Hospital at home units allow the treatment of moderate and severe infections by administering intravenous antibiotics to patients who would otherwise have to remain hospitalised. Increasing antibiotic resistance adds an element of difficulty to outpatient treatment of infections because multiple daily doses of antimicrobials or combinations of antimicrobials are sometimes required. This manuscript discusses some of the challenges of outpatient management of infections with multidrug-resistant microorganisms and shows the main antibiotic resistances and the outcomes of treatment of these infections in Spanish home hospitalisation units.
Insights
Hospital at home units effectively treat infections with intravenous antibiotics. Managing multidrug-resistant organisms in these settings presents challenges due to complex antimicrobial regimens.
Area of Science:
- Infectious Diseases
- Hospital Administration
- Pharmacology
Background:
- Hospital at home units offer an alternative to inpatient care for moderate to severe infections.
- Increasing antibiotic resistance complicates outpatient treatment, often necessitating complex antimicrobial regimens.
- Multidrug-resistant organisms (MDROs) pose a significant challenge to effective infection management in community settings.
Purpose of the Study:
- To discuss the challenges associated with the outpatient management of infections caused by multidrug-resistant microorganisms.
- To present key antibiotic resistance patterns observed in Spanish home hospitalization units.
- To evaluate the treatment outcomes for infections involving MDROs within these units.
Main Methods:
- Review of clinical data from patients treated in Spanish home hospitalization units.
- Analysis of antibiotic resistance profiles of common pathogens.
- Assessment of treatment success and failure rates for MDRO infections.
Main Results:
- Hospital at home services are viable for treating complex infections requiring intravenous antibiotics.
- Specific MDROs present unique challenges in outpatient settings.
- Treatment outcomes vary depending on the specific microorganism and prescribed antibiotic regimen.
Conclusions:
- Home hospitalization is a feasible model for managing infections, even those caused by MDROs.
- Careful selection of antibiotics and monitoring are crucial for successful outpatient treatment of MDROs.
- Further research is needed to optimize treatment strategies for MDRO infections in home-based care settings.
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