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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Functional intersections between extracellular vesicles and oncolytic therapies

Ryan A Clark1, Zoe G Garman2, Richard J Price3

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA.

Trends in Pharmacological Sciences
|October 2, 2021
PubMed

Insights

Minimally invasive cancer therapies like radiotherapy and photodynamic therapy significantly impact extracellular vesicles (EVs). Understanding these effects is key to developing advanced EV-based drug delivery systems for cancer treatment.

Area of Science:

  • Oncology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Minimally invasive focal therapies are crucial for nonviral oncolysis in cancer treatment.
  • Extracellular vesicles (EVs) play a significant role in tumor progression and are modulated by oncolytic therapies.
  • A deeper understanding of biological responses is needed to optimize oncolytic therapies and combinations.

Purpose of the Study:

  • To review the impact of focal therapies on EV biology.
  • To highlight advances in EV-based drug delivery systems utilizing these therapies.

Main Methods:

  • Review of current literature on radiotherapy, photodynamic therapy (PDT), and therapeutic ultrasound (TUS) and their effects on EVs.
  • Analysis of recent developments in EV-mediated drug delivery strategies.

Main Results:

  • Focal therapies like radiotherapy, PDT, and TUS potently modulate EV production and content.
  • EVs can be engineered for targeted drug delivery, enhanced by oncolytic therapies.
  • Emerging strategies leverage therapeutic modalities to improve EV-based cancer treatments.

Conclusions:

  • Modulation of EVs by focal therapies offers new avenues for cancer treatment strategies.
  • EV-based drug delivery systems show promise when combined with oncolytic focal therapies.
  • Further research into EV-therapy interactions can optimize combination approaches for improved patient outcomes.
Keywords:
cancerexosomesextracellular vesiclesfocal therapyoncolytic therapytherapeutic ultrasound

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