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Tendon and multiomics: advantages, advances, and opportunities
Paula Sarmiento1, Dianne Little2,3
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. psarmien@purdue.edu.
NPJ Regenerative Medicine
|October 2, 2021
Summary
Multiomics, which integrates multiple
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Orthopedics
Background:
- Tendon healing results in fibrosis, impairing function and increasing re-injury risk.
- The underlying biology of tendon degeneration and regeneration remains incompletely understood.
- Metabolic factors influencing tendinopathy outcomes require further investigation.
Purpose of the Study:
- To review the current literature on multiomics in tendon research.
- To explore the potential of multiomics platforms for enhancing tendon regeneration.
- To identify knowledge gaps and future research directions in tendon multiomics.
Main Methods:
- Literature review of multiomics studies in tendon.
- Analysis of 'omics data for tendon biology, degeneration, healing, and engineered tissues.
- Assessment of regenerative and therapeutic approaches informed by multiomics.
Main Results:
- Multiomics aids in studying tendon biology, hierarchical complexity, and demographic factors.
- Comparative analyses across tendon pathologies reveal insights into degeneration and healing.
- 'Omics platforms are valuable for characterizing in vitro engineered tendon phenotypes.
Conclusions:
- Multiomics offers significant potential to advance tendon tissue engineering and regenerative medicine.
- Future research should focus on increasing subject diversity, understanding tendon heterogeneity, and informing therapeutic strategies.
- Further investigation into the development of tendon pathology is warranted.
