Related Experiment Video
Updated: Oct 18, 2025

Deep Neuromuscular Blockade Leads to a Larger Intraabdominal Volume During Laparoscopy
Published on: June 25, 2013
Sugammadex Reduces PACU Recovery Time after Abdominal Surgery Compared with Neostigmine
Jin Deng1, Maha Balouch1, Michael Albrink1
1From the Morsani College of Medicine, University of South Florida, Tampa, TEAMHealth Anesthesia, Tampa, Florida, and the Division of General Surgery, Tampa General Hospital, Tampa, Florida.
Objective:
This study blindly evaluated sugammadex compared with neostigmine on length of stay in the postanesthesia care unit (PACU).
Methods:
Fifty patients undergoing elective laparoscopic cholecystectomy or abdominal wall hernia repair consented to receive either sugammadex (2 mg/kg) or neostigmine (0.07 mg/kg) for the reversal of rocuronium neuromuscular blockade. Reversal agents were administered during surgical closing, and the train of four was measured until a twitch ratio of T4:T1 ≥ 0.9 was obtained to signify a robust reversal. Postreversal outcomes also were measured during PACU stay. Aldrete scores, pain visual analog scale score, and nausea were measured during the PACU stay.
Results:
Patients receiving sugammadex experienced a shorter PACU stay at the time of discharge than patients receiving neostigmine, by an average of 12 minutes (P < 0.05).
Conclusions:
Sugammadex patients had a significantly shorter PACU stay.
More Related Videos
Related Concept Videos
Depolarizing Blockers: Pharmocokinetics
Skeletal Muscle Relaxants: Adverse Effects
Unlike...
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions
Although all competitive neuromuscular blockers are designed...
Skeletal Muscle Relaxants: Therapeutic Uses
Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacokinetics
Instead, they are transported by the blood to different tissues. Muscles with a greater blood supply (arteries) and blood flow receive more...
Parenteral Anesthetics: Overview

