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On dose cube pixel spacing pre-processing for features extraction stability in dosiomic studies.

L Placidi1, D Cusumano2, J Lenkowicz2

  • 1Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Roma, Italy; Istituto di Radiologia, Università Cattolica del Sacro Cuore, Roma, Italy.

Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)
|October 2, 2021
PubMed
Summary

Dosiomics feature stability varies with pixel spacing. Researchers found some features are stable across different spacings, but reporting pixel spacing is crucial for dosiomic studies.

Keywords:
Dose cube pixel spacingDose distribution texture analysisDosiomicsFeatures stability

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Area of Science:

  • Radiotherapy Physics
  • Medical Imaging Analysis
  • Quantitative Imaging

Background:

  • Dosiomics quantifies radiotherapy dose distributions using spatial and statistical features.
  • Understanding the impact of technical variations on dosiomics is essential for clinical translation.

Purpose of the Study:

  • To investigate the stability of dosiomics feature extraction when varying dose cube pixel spacing.
  • To identify dosiomic features robust to changes in dose grid resolution and calculation algorithms.

Main Methods:

  • Generated a dataset from 17 dose distributions with varying grid resolutions and calculation algorithms.
  • Extracted dosiomics features from four regions of interest (ROIs) using four different pixel spacings.
  • Analyzed feature stability using coefficient of variation (CV) and intraclass correlation coefficient (ICC).

Main Results:

  • Dose cube pixel spacing significantly impacts dosiomics features, with higher variability observed for PTV ROIs and specific feature families.
  • Features from the grey level co-occurrence matrix in the RING ROI demonstrated the lowest variability.
  • Identified specific dosiomic features with ICC > 0.95, indicating stability across different pixel spacings.

Conclusions:

  • Dosiomic studies must report dose cube pixel spacing alongside grid resolution and dose calculation algorithm.
  • Certain dosiomic features exhibit sufficient stability for use in studies employing varying pixel spacings.