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Increased behavioural problems associated with corticosteroid use in children with nephrotic syndrome: a Southeast

Mohamad Nizam Mahmud1, Azizah Othman1, Mohamad Ikram Ilias1

  • 1Department of Paediatrics, School of Medical Sciences, Universiti Sains Malaysia; Hospital Universiti Sains Malaysia, Health Campus, Universiti Sains Malaysia, Kelantan, Malaysia.

Singapore Medical Journal
|October 3, 2021
PubMed

Insights

Children with idiopathic nephrotic syndrome (INS) on steroid therapy experience more psychological problems, including anxiety and aggressiveness. These issues correlate with corticosteroid dosage and cushingoid features.

Area of Science:

  • Pediatric Nephrology
  • Child Psychology

Background:

  • Idiopathic nephrotic syndrome (INS) is a common kidney disease in children.
  • Steroid therapy is the primary treatment for INS, but can have significant side effects.

Purpose of the Study:

  • To investigate psychological problems in children with INS undergoing steroid therapy.
  • To compare the psychological well-being of children with INS to healthy controls.

Main Methods:

  • A prospective cohort study involving 140 children (INS group and healthy control group).
  • Child Behavioural Checklist (CBCL) administered to parents to assess emotional and psychological issues.
  • Mann-Whitney U test used for statistical analysis of CBCL scores.

Main Results:

  • Children with INS showed significantly higher total CBCL scores compared to controls.
  • Specific increases in withdrawal, somatic complaints, anxiety, and aggressiveness were noted in the INS group.
  • Higher corticosteroid dosage and cushingoid features were positively associated with internalizing psychological problems in children with INS.

Conclusions:

  • Children with INS on corticosteroid treatment exhibit increased internalizing and externalizing psychological problems.
  • Psychological support may be beneficial for children with INS during steroid therapy.
Abstract

Keywords:
Corticosteroidexternalisinginternalisingnephrotic syndromepsychology

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