Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

An evolutionary reduction principle for genetic modifiers.

M W Feldman, U Liberman

    Proceedings of the National Academy of Sciences of the United States of America
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Cultural niche construction and human evolution.

    Journal of evolutionary biology·2017
    Same author

    Tracking and predicting hand, foot, and mouth disease (HFMD) epidemics in China by Baidu queries.

    Epidemiology and infection·2017
    Same author

    Family structure and quality of life of elders in rural China: the role of the new rural social pension.

    Journal of aging & social policy·2014
    Same author

    The role of cultural transmission in human demographic change: an age-structured model.

    Theoretical population biology·2013
    Same author

    The coevolution of long-term pair bonds and cooperation.

    Journal of evolutionary biology·2013
    Same author

    Forced bachelors, migration and HIV transmission risk in the context of China's gender imbalance: a meta-analysis.

    AIDS care·2012
    Same journal

    Tau protein as a regulator of mitochondrial function and dynamics.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    A scalable, dividing cell model for the robust propagation and quantification of human sporadic Creutzfeldt-Jakob disease prions.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Epigenetic regulation of mesenchymal BMP signaling directs postnatal organ innervation.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Single-shot wide-field biochemical imaging at 1 kHz frame rate.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    Morphogenesis and topological evolution of a frustrated nematic liquid crystal under confinement.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    Same journal

    B cell-intrinsic CXCR3 drives efficient generation of ectopic pulmonary germinal center responses to influenza A virus infection.

    Proceedings of the National Academy of Sciences of the United States of America·2026
    See all related articles

    This study explores how modifier genes influence evolution. New alleles can invade populations if their genetic modification rates are lower than the existing average, impacting evolutionary trajectories.

    Area of Science:

    • Evolutionary genetics
    • Population genetics
    • Theoretical biology

    Background:

    • Major genes are subject to viability selection.
    • Modifier loci can influence recombination, mutation, or migration rates.
    • Modifier loci are selectively neutral and can possess multiple alleles.

    Purpose of the Study:

    • To investigate the joint evolution of major genes and neutral modifier loci.
    • To identify conditions for the establishment of new alleles under modifier control.
    • To analyze the stability of evolutionary equilibria.

    Main Methods:

    • Mathematical modeling of gene evolution.
    • Analysis of viability selection and neutral modifiers.
    • Investigation of recombination, mutation, and migration dynamics.

    Related Experiment Videos

    Main Results:

    • Existence of viability-analogous Hardy-Weinberg (VAHW) equilibria for modifier alleles.
    • New alleles can invade if their marginal modification rates are below the population average.
    • Characterization of stability properties for VAHW equilibria.

    Conclusions:

    • Neutral modifier loci can significantly impact the evolution of major genes.
    • VAHW equilibria provide a framework for understanding modifier allele dynamics.
    • Allele invasion is contingent on modification rates relative to population averages.