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The impact of computed tomography-derived aortic atheroma volume on prognosis after transcatheter aortic valve

Hiroshi Fujita1, Takayoshi Toba1, Keisuke Miwa1

  • 1Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

International Journal of Cardiology
|October 3, 2021
PubMed

Insights

Aortic atheroma volume (AAV) predicts mortality after transcatheter aortic valve replacement (TAVR). Abdominal AAV is a key predictor of all-cause mortality, highlighting its prognostic value in TAVR patients.

Area of Science:

  • Cardiovascular Imaging
  • Interventional Cardiology
  • Prognostic Biomarkers

Background:

  • Prognostic implications of aortic atheroma extent post-TAVR remain unclear.
  • Aortic atheroma volume (AAV) and its segmental distribution require evaluation in TAVR patients.

Purpose of the Study:

  • To assess the prognostic value of pre-procedural AAV in patients undergoing TAVR.
  • To investigate the impact of thoracic (TAAV) and abdominal (AbAAV) AAV on mortality after TAVR.

Main Methods:

  • Computed tomography (CT) scans of 143 severe aortic stenosis patients before TAVR were analyzed.
  • Aortic atheroma volume (AAV) was quantified and segmented into thoracic (TAAV) and abdominal (AbAAV) components.

Main Results:

  • Higher overall AAV correlated with increased all-cause and cardiac mortality.
  • Abdominal AAV, but not TAAV, was significantly associated with higher all-cause and cardiac mortality.
  • Abdominal AAV emerged as an independent predictor of all-cause mortality post-TAVR.

Conclusions:

  • Aortic atheroma volume (AAV) is a significant predictor of mortality following TAVR.
  • Pre-procedural CT-derived AAV assessment aids in predicting TAVR patient prognosis.
  • Further large-scale studies are warranted to confirm these findings.
Abstract

Keywords:
Aortic atheroma volumeAortic stenosisAtherosclerosisComputed tomographyTranscatheter aortic valve replacement

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