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Updated: Oct 18, 2025
MicroRNA-based Regulation of Picornavirus Tropism
Published on: February 6, 2017
Role of microRNAs in COVID-19 with implications for therapeutics
Nahid Arghiani1, Tracy Nissan1, Maryam M Matin2
1Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden; School of Life Science, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, United Kingdom.
Abstract:
COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA approved drug against SARS-CoV-2 yet. miRNA-directed gene regulation controls the majority of biological processes. In addition, the development and progression of several human diseases are associated with dysregulation of miRNAs. In this regard, it has been shown that changes in miRNAs are linked to severity of COVID-19 especially in patients with respiratory diseases, diabetes, heart failure or kidney problems. Therefore, targeting these small noncoding-RNAs could potentially alleviate complications from COVID-19. Here, we will review the roles and importance of host and RNA virus encoded miRNAs in COVID-19 pathogenicity and immune response. Then, we focus on potential miRNA therapeutics in the patients who are at increased risk for severe disease.
Insights
MicroRNAs (miRNAs) play a crucial role in COVID-19 severity and immune response. Targeting these small RNAs offers potential therapeutic strategies for high-risk patients, especially those with comorbidities.
Area of Science:
- Biochemistry
- Virology
- Genetics
Background:
- COVID-19, caused by SARS-CoV-2, is a severe respiratory illness with no specific FDA-approved treatment.
- MicroRNAs (miRNAs) are key regulators of gene expression implicated in various diseases.
- Dysregulated miRNAs are linked to COVID-19 severity, particularly in patients with underlying conditions.
Purpose of the Study:
- To review the role of host and viral miRNAs in COVID-19 pathogenesis and immune response.
- To explore potential miRNA-based therapeutic strategies for severe COVID-19 cases.
Main Methods:
- Literature review focusing on miRNA involvement in COVID-19.
- Analysis of studies linking miRNA dysregulation to disease severity and immune response.
- Identification of potential miRNA targets for therapeutic intervention.
Main Results:
- Host and SARS-CoV-2 encoded miRNAs significantly influence COVID-19 pathogenicity.
- miRNA profiles correlate with COVID-19 severity in patients with comorbidities like diabetes and heart failure.
- Specific miRNAs are identified as potential biomarkers and therapeutic targets.
Conclusions:
- miRNAs are critical players in COVID-19, affecting disease progression and immune reactions.
- Targeting specific miRNAs presents a promising avenue for developing novel therapeutics against severe COVID-19.
- Further research into miRNA therapeutics could improve outcomes for high-risk populations.
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