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Updated: Oct 18, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis
Published on: August 26, 2025
[Isolated Pulmonary Valve Endocarditis Accompanying Multiple Pulmonary Embolisms:Report of a Case]
Jun Osaki1, Hideyuki Fumoto, Motonori Uchino
1Department of Cardiovascular Surgery, Oosumi Kanoya Hospital, Kanoya, Japan.
Abstract:
Isolated pulmonary valve infective endocarditis is rare and accounts for only 1.5% to 2.0% of all cases of infective endocarditis. We present a case of isolated pulmonary valve endocarditis, which was successfully treated by pulmonary valve replacement. A 69-year-old man presented with fever and was diagnosed with active pulmonary valve infective endocarditis. He had no apparent predisposing factors. Blood cultures were positive for Streptococcus viridans, and transesophageal echocardiography showed mobile vegetation. His condition improved transiently with intravenous antibiotic therapy;however, high fever and reduced oxygen saturation recurred. Computed tomography showed multiple infiltrative shadows suggesting septic pulmonary embolisms. Urgent surgery was indicated because antibiotic treatment was ineffective. During the operation, we found that vegetation had destroyed all pulmonary leaflets. We performed pulmonary valve replacement with a stented bioprosthetic valve as well as enlargement of the right ventricular outflow tract with a bovine pericardial patch. The postoperative course was uneventful. Antibiotic therapy was continued for six weeks after surgery. For two years since surgery, the patient has experienced no recurrence of infection.
Insights
Isolated pulmonary valve infective endocarditis is rare. This case highlights successful treatment via pulmonary valve replacement in a patient with Streptococcus viridans infection and septic pulmonary embolisms.
Area of Science:
- Cardiology
- Infectious Diseases
- Cardiac Surgery
Background:
- Isolated pulmonary valve infective endocarditis is a rare condition, representing 1.5% to 2.0% of all infective endocarditis cases.
- Predisposing factors are often absent in patients with pulmonary valve endocarditis.
Observation:
- A 69-year-old male presented with fever and was diagnosed with active pulmonary valve infective endocarditis.
- Blood cultures identified Streptococcus viridans; transesophageal echocardiography revealed mobile vegetation.
- Despite initial antibiotic therapy, the patient experienced recurrent fever and reduced oxygen saturation, with CT scans indicating septic pulmonary embolisms.
Findings:
- Urgent surgical intervention was necessary due to ineffective antibiotic treatment.
- Intraoperative findings revealed extensive destruction of the pulmonary valve leaflets by vegetation.
- Pulmonary valve replacement with a stented bioprosthetic valve and right ventricular outflow tract enlargement using a bovine pericardial patch were performed.
Implications:
- Successful surgical management of isolated pulmonary valve infective endocarditis can be achieved with valve replacement.
- This approach, combined with a full course of antibiotics, led to a favorable long-term outcome with no recurrence of infection for two years.
- The case underscores the importance of considering surgical intervention when antibiotic therapy fails in pulmonary valve endocarditis, especially with complications like septic pulmonary embolisms.
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