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Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

47
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

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Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Related Experiment Video

Updated: Oct 18, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

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Myositis ossificans: a rare neonatal presentation.

Chelsea B Dennison1, Ivey R Royall2, Kimberly M Beavers2

  • 1Department of Diagnostic Radiology, AdventHealth Orlando, 601 E. Rollins St., Orlando, FL, 32803, USA. chelsea.dennison.md@adventhealth.com.

Pediatric Radiology
|October 3, 2021
PubMed
Summary

Myositis ossificans, a soft-tissue pseudotumor, is rare in infants. This study details an unusual case in the perinatal period, highlighting key imaging findings for early diagnosis.

Keywords:
Computed tomographyMagnetic resonance imagingMassMyositis ossificansNeonatePseudotumorRadiographySkeletal muscleSoft tissue

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Area of Science:

  • Orthopedics
  • Radiology
  • Pediatric Pathology

Background:

  • Myositis ossificans is a benign, ossifying soft-tissue pseudotumor.
  • Typically affects men aged 30-40 years post-trauma.
  • Extremely rare in children under 10 years old.

Observation:

  • This report presents an exceptionally unusual case of myositis ossificans.
  • The condition manifested in the immediate perinatal period, shortly after birth.
  • Key imaging findings that aid in differentiation are reviewed.

Findings:

  • Myositis ossificans presents unique imaging characteristics distinct from malignant soft-tissue tumors.
  • Early and accurate differentiation is crucial for patient management.
  • This case underscores the possibility of congenital or perinatal onset.

Implications:

  • Accurate diagnosis of myositis ossificans prevents unnecessary and potentially harmful procedures.
  • Recognizing rare presentations like this improves diagnostic capabilities in neonates.
  • Understanding the imaging spectrum is vital for pediatric radiologists and orthopedic surgeons.