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No structural brain alterations in new daily persistent headache - a cross sectional VBM/SBM study.

Steffen Naegel1,2, Julia Zeller2,3, Anders Hougard4

  • 1Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.

Cephalalgia : an International Journal of Headache
|October 4, 2021
PubMed
Summary

This study found no grey matter changes in patients with new daily persistent headache (NDPH). Advanced MRI techniques did not reveal structural brain differences, suggesting NDPH pathophysiology may not involve grey matter alterations.

Keywords:
New daily persistent headachebrain structural correlatevoxel-based morphometry

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Area of Science:

  • Neurology
  • Neuroimaging
  • Headache Medicine

Background:

  • New daily persistent headache (NDPH) is a rare primary headache disorder.
  • NDPH is characterized by a distinct, remembered onset and rapid chronification.
  • The underlying pathophysiology of NDPH remains poorly understood.

Purpose of the Study:

  • To investigate potential grey matter alterations in NDPH patients.
  • To enhance the pathophysiological understanding of this rare headache disorder.
  • To explore structural brain changes associated with NDPH.

Main Methods:

  • Utilized magnetic resonance imaging (MRI) with voxel-based and surface-based morphometry.
  • Studied 23 patients with NDPH and 23 age- and gender-matched healthy controls.
  • Employed statistical parametric mapping and FSL (FMRIB Software Library) analysis across three sites.

Main Results:

  • No significant grey matter changes were detected in NDPH patients compared to controls.
  • Sophisticated and cross-checked morphometric analyses yielded negative findings.
  • The study did not identify structural brain alterations in the studied cohort.

Conclusions:

  • The absence of grey matter changes in NDPH does not support a role for structural alterations in its pathophysiology.
  • Findings contribute to the ongoing discussion on structural changes in primary headache disorders.
  • Further research is required to elucidate the mechanisms underlying NDPH.