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Updated: Oct 18, 2025

Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish

Invasive Behavior of Human Breast Cancer Cells in Embryonic Zebrafish

Published on: April 25, 2017

Carcinogenesis Models Using Small Fish.

Takashi Kawasaki¹, Yuki Shimizu¹

¹Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST).

Chemical & Pharmaceutical Bulletin

|October 4, 2021

Summary

This summary is machine-generated.

Small fish like zebrafish are increasingly used in cancer research due to their advantageous traits. Technological advances in gene transfer and genome editing are creating better animal models to mimic human cancer pathology.

Keywords:

carcinogenesis medaka mutagenesis transgenesis zebrafish

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Area of Science:

* Life Science Research
* Comparative Oncology
* Model Organism Development

Background:

* Experimental animals are crucial for life science research, particularly in cancer studies.
* Small fish, including zebrafish and medaka, are the second most frequently used model species after rats and mice.
* Advantages of fish models include small size, transparency, genetic manipulability, ease of handling, and human gene homology.

Purpose of the Study:

* To review technological advancements in producing small fish models for cancer research.
* To highlight how new technologies improve the accuracy and efficiency of carcinogenesis models.
* To discuss the future potential of small fish in advancing cancer studies.

Main Methods:

* Review of technological advances in chemical carcinogenesis and mutagenesis in small fish.
* Exploration of gene transfer technologies for controlling cancer-related gene expression.
* Discussion of genome editing technologies for precise gene disruption in fish models.

Main Results:

* Gene transfer allows for spatiotemporal control of gene expression using tissue-specific promoters and external stimuli (light, heat, chemicals).
* Genome editing offers more specific and efficient gene disruption compared to traditional mutagenesis.
* These advancements are enhancing the utility of small fish as preclinical cancer models.

Conclusions:

* Technological progress is significantly improving small fish carcinogenesis models.
* Future models are expected to more closely mimic human cancer pathology.
* Small fish hold great promise for future cancer research applications.